Presentation of BMP-2 from a Soft Biopolymeric Film Unveils its Activity on Cell Adhesion and Migration

T. Crouzier (1) , L. Fourel (1) , T. Boudou (1) , Corinne Albiges-Rizo (2) , C. Picart (1)

1 IMBM
2 DySAD - Dynamique des systèmes d'adhérence et différenciation

The dramatic effect of morphogenetic protein 2 (BMP-2), presented to cells in a "matrix bound" manner is described. BMP-2 is either delivered in solution or bound to a thin film made of poly(lysine) and hyaluronan. In this later case only, a striking effect of BMP-2 on cell adhesion and migration is observed.

Mots clés: thin films; stiffness; growth factors; biopolymeric materials; drug delivery

T. Crouzier, L. Fourel, T. Boudou, Corinne Albiges-Rizo, C. Picart. Presentation of BMP-2 from a Soft Biopolymeric Film Unveils its Activity on Cell Adhesion and Migration. Advanced Materials, 2011, 23 (12), pp.H111-H118. ⟨10.1002/adma.201004637⟩. ⟨hal-00670226⟩