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Nano-assemblies with core-forming hydrophobic polypeptide via polymerization-induced self-assembly (PISA)

Abstract : The aim of this study is to produce self-assembled structures with hydrophobic polypeptide cores via Reversible Addition–Fragmentation chain Transfer (RAFT) – mediated Polymerisation-Induced Self-Assembly (PISA). Hydrophilic poly(glycerol monomethacrylate) macromolecular chain transfer agents (PGMA mCTAs) were used to polymerize the self-assembling peptide monomers, resulting in the formation of diblock copolymer nano objects. Methacrylamide derivatives containing self-assembling tripeptides MAm-GFF (MAm-Gly-Phe-Phe-NH2) and MAm-FGD (MAm-Phe-Gly-Asp-NH2) were used as hydrophobic monomers. The self-assembling behaviours of these monomers mainly derive from the interactions of the phenylalanine residues, however their difference in hydrophobicity required different polymerization conditions. MAm-GFF was polymerized in the presence of organic solvent (ethanol or acetonitrile), under either dispersion or emulsion polymerization, while MAm-FGD was polymerized under aqueous dispersion conditions. PGMA-b-P(MAm-FGD) obtained from aqueous PISA typically formed fibrous structures while a range of morphologies such as fibre-, flake-, and leaf-like or spherical vesicles were obtained for PGMA-b-P(MAm-GFF) depending on the copolymer composition and solvent used. In all cases the peptides self-assembling core had a crucial influence on the final morphologies.
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https://hal.archives-ouvertes.fr/hal-03005857
Contributor : Mona Semsarilar Connect in order to contact the contributor
Submitted on : Thursday, October 14, 2021 - 3:36:42 PM
Last modification on : Wednesday, November 17, 2021 - 2:24:03 PM

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T. Dao, Lubomir Vezenkov, Gilles Subra, Vincent Ladmiral, Mona Semsarilar. Nano-assemblies with core-forming hydrophobic polypeptide via polymerization-induced self-assembly (PISA). Polymer Chemistry, Royal Society of Chemistry - RSC, 2021, 12, pp.113-121. ⟨10.1039/d0py00793e⟩. ⟨hal-03005857⟩

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