Application of two job indices for general occupational demands in a pooled analysis of case-control studies on lung cancer
Jan Hovanec
(1, 2)
,
Jack Siemiatycki
(3)
,
David Conway
(4)
,
Ann Olsson
(5)
,
Pascal Guenel
(6)
,
Danièle Luce
(7, 8)
,
Karl-Heinz Joeckel
(9)
,
Hermann Pohlabeln
(10)
,
Wolfgang Ahrens
(11, 10)
,
Stefan Karrasch
(12)
,
Heinz-Erich Wichmann
(13)
,
Per Gustavsson
(14)
,
Dario Consonni
(15)
,
Franco Merletti
(16)
,
Lorenzo Richiardi
(16)
,
Lorenzo Simonato
(17)
,
Cristina Fortes
(18)
,
Marie-Elise Parent
,
John R. Mclaughlin
(19)
,
Paul Demers
,
Maria Teresa Landi
(20)
,
Neil Caporaso
(20)
,
Guillermo Fernandez-Tardon
(21, 22)
,
David Zaridze
(23)
,
Beata Swiatkowska
(24)
,
Tamas Pandics
(25)
,
Jolanta Lissowska
(26)
,
Eleonora Fabianova
,
John K. Field
(27)
,
Dana Mates
(28)
,
Vladimir Bencko
(29)
,
Lenka Foretova
(30)
,
Vladimir Janout
(31)
,
Hans Kromhout
(32)
,
Roel Vermeulen
(32)
,
Paolo Boffetta
(33, 34)
,
Kurt Straif
(5)
,
Joachim Schuz
(5)
,
Swaantje Casjens
(1, 2)
,
Beate Pesch
(1, 2)
,
Thomas Bruening
(1, 2)
,
Thomas Behrens
(2, 1)
1
RUB -
Ruhr University Bochum = Ruhr-Universität Bochum
2 IPA - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance
3 CR CHUM - Centre de Recherche du Centre Hospitalier de l’Université de Montréal
4 University of Glasgow
5 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
6 CESP - Centre de recherche en épidémiologie et santé des populations
7 EHESP - École des Hautes Études en Santé Publique [EHESP]
8 Irset - Institut de recherche en santé, environnement et travail
9 Ruhrlandklinik University Hospital
10 Leibniz Institute for Prevention Research and Epidemiology - BIPS
11 Universität Bremen
12 Helmholtz Zentrum München = German Research Center for Environmental Health
13 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
14 Karolinska Institute
15 Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
16 UNITO - Università degli studi di Torino = University of Turin
17 AOUP - Azienda Ospedale Università di Padova = Hospital-University of Padua
18 IRCCS - Istituti di Ricovero e Cura a Carattere Scientifico
19 University of Toronto
20 NCI-NIH - National Cancer Institute [Bethesda]
21 Universidad de Oviedo [Oviedo]
22 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
23 N.N. Blokhin National Medical Research Center of Oncology
24 NIOM - Nofer Institute of Occupational Medicine
25 National Public Health Centre,
26 Medical University of Warsaw - Poland
27 University of Liverpool
28 INSP - National Institute of Public Health [Romania]
29 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
30 MMCI - Masaryk Memorial Cancer Institute
31 Palacky University Olomouc
32 Universiteit Utrecht
33 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
34 SBU - Stony Brook University [SUNY]
2 IPA - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance
3 CR CHUM - Centre de Recherche du Centre Hospitalier de l’Université de Montréal
4 University of Glasgow
5 CIRC - IARC - Centre International de Recherche contre le Cancer - International Agency for Research on Cancer
6 CESP - Centre de recherche en épidémiologie et santé des populations
7 EHESP - École des Hautes Études en Santé Publique [EHESP]
8 Irset - Institut de recherche en santé, environnement et travail
9 Ruhrlandklinik University Hospital
10 Leibniz Institute for Prevention Research and Epidemiology - BIPS
11 Universität Bremen
12 Helmholtz Zentrum München = German Research Center for Environmental Health
13 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
14 Karolinska Institute
15 Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
16 UNITO - Università degli studi di Torino = University of Turin
17 AOUP - Azienda Ospedale Università di Padova = Hospital-University of Padua
18 IRCCS - Istituti di Ricovero e Cura a Carattere Scientifico
19 University of Toronto
20 NCI-NIH - National Cancer Institute [Bethesda]
21 Universidad de Oviedo [Oviedo]
22 CIBERESP - Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health
23 N.N. Blokhin National Medical Research Center of Oncology
24 NIOM - Nofer Institute of Occupational Medicine
25 National Public Health Centre,
26 Medical University of Warsaw - Poland
27 University of Liverpool
28 INSP - National Institute of Public Health [Romania]
29 UK - Univerzita Karlova [Praha, Česká republika] = Charles University [Prague, Czech Republic]
30 MMCI - Masaryk Memorial Cancer Institute
31 Palacky University Olomouc
32 Universiteit Utrecht
33 UNIBO - Alma Mater Studiorum Università di Bologna = University of Bologna
34 SBU - Stony Brook University [SUNY]
Jan Hovanec
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- PersonId : 1112938
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Pascal Guenel
- Fonction : Auteur
- PersonId : 757378
- ORCID : 0000-0002-8359-518X
- IdRef : 032371578
Danièle Luce
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- IdHAL : daniele-luce
- ORCID : 0000-0002-1708-4584
- IdRef : 097726745
Marie-Elise Parent
- Fonction : Auteur
Paul Demers
- Fonction : Auteur
Eleonora Fabianova
- Fonction : Auteur
Kurt Straif
- Fonction : Auteur
- PersonId : 765183
- ORCID : 0000-0003-1402-2406
Résumé
Objectives We investigated general job demands as a risk factor for lung cancer as well as their role in the association between occupational prestige and lung cancer. Methods In 13 case-control studies on lung cancer, as part of the international SYNERGY project, we applied indices for physical (PHI) and psychosocial (PSI) job demands - each with four categories (high to low). We estimated odds ratios (OR) and 95% confidence intervals (CI) for lung cancer by unconditional logistic regression, separately for men and women and adjusted for study centre, age, smoking behavior, and former employment in occupations with potential exposure to carcinogens. Further, we investigated, whether higher risks among men with low occupational prestige (Treiman's Standard International Occupational Prestige Scale) were affected by adjustment for the job indices. Results In 30 355 men and 7371 women, we found increased risks (OR) for lung cancer with high relative to low job demands in both men [PHI 1.74 (95% CI 1.56-1.93), PSI 1.33 (95% CI 1.17-1.51)] and women [PHI 1.62 (95% CI 1.24-2.11), PSI 1.31 (95% CI 1.09-1.56)]. OR for lung cancer among men with low occupational prestige were slightly reduced when adjusting for PHI [low versus high prestige OR from 1.44 (95% CI 1.32-1.58) to 1.30 (95% CI 1.17-1.45)], but not PSI. Conclusions Higher physical job demands were associated with increased risks of lung cancer, while associations for higher psychosocial demands were less strong. In contrast to physical demands, psychosocial demands did not contribute to clarify the association of occupational prestige and lung cancer.
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