Functional Myoglobin Model Composed of a Strapped Porphyrin/Cyclodextrin Supramolecular Complex with an Overhanging COOH That Increases O(2)/CO Binding Selectivity in Aqueous Solution - Organométalliques : Matériaux et Catalyse Accéder directement au contenu
Article Dans Une Revue Inorganic Chemistry Année : 2021

Functional Myoglobin Model Composed of a Strapped Porphyrin/Cyclodextrin Supramolecular Complex with an Overhanging COOH That Increases O(2)/CO Binding Selectivity in Aqueous Solution

Résumé

A water-soluble strapped iron(III)tetraarylporphyrin () bearing two propylpyridinium groups at the side chains and a carboxylic acid group at the overhanging position of the strap was synthesized to mimic the function of myoglobin with the distal polar functionality in aqueous solution. forms a stable 1:1 inclusion complex with a per--methylated β-cyclodextrin dimer having a pyridine linker (), providing a hydrophobic environment and a proximal fifth ligand to stabilize the O-complex. The ferrous complex () binds both O and CO in aqueous solution. The O and CO binding affinities ( and ) and half-life time () of the O complex of are 6.3 and 0.021 Torr, and 7 h, respectively, at pH 7 and 25 °C. The control compound without the strap structure () has similar oxygen binding characteristics ( = 8.0 Torr), but much higher CO binding affinity ( = 3.8 × 10 Torr), and longer (30 h). The O and CO kinetics indicate that the strapped structure in inhibits the entrance of these gaseous ligands into the iron(II) center, as evidenced by lower and values. Interestingly, the CO complex of is significantly destabilized (relatively larger ), while the value is much smaller than that of , resulting in significantly increased O/CO selectivity (reduced value, where = / = 320) in compared to ( = 21000).
Fichier principal
Vignette du fichier
Mao et al - 2021 - A Functional Myoglobin Model Composed of a Strapped Porphyrin.pdf (2.99 Mo) Télécharger le fichier
Mao_ic1c01628_si_001.pdf (9.1 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03333762 , version 1 (06-10-2021)

Identifiants

Citer

Qiyue Mao, Pradip K Das, Stéphane Le Gac, Bernard Boitrel, Vincent Dorcet, et al.. Functional Myoglobin Model Composed of a Strapped Porphyrin/Cyclodextrin Supramolecular Complex with an Overhanging COOH That Increases O(2)/CO Binding Selectivity in Aqueous Solution. Inorganic Chemistry, 2021, 60 (16), pp.12392-12404. ⟨10.1021/acs.inorgchem.1c01628⟩. ⟨hal-03333762⟩
63 Consultations
56 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More