Dynamic brain effective connectivity analysis based on low-rank canonical polyadic decomposition: application to epilepsy

Pierre-Antoine Chantal (1) , Ahmad Karfoul (1) , Anca Nica (1, 2) , Régine Le Bouquin Jeannès (1)

1 LTSI - Laboratoire Traitement du Signal et de l'Image
2 Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Ponchaillou]

In this paper, a new method to track brain effective connectivity networks in the context of epilepsy is proposed. It relies on the combination of partial directed coherence with a constrained low-rank canonical polyadic tensor decomposition. With such combination being established, the most dominating directed graph structures underlying each time window of intracerebral electroencephalographic signals are optimally inferred. Obtained time and frequency signatures of inferred brain networks allow respectively to track the time evolution of these networks and to define frequency bands on which they are operating. Besides, the proposed method allows also to track brain connectivity networks through several epileptic seizures of the same patient. Understanding the most dominating directed graph structures over epileptic seizures and investigating their behavior over time and frequency plans are henceforth possible. Since only few but the the most important directed connections in the graph structure are of interest and also for a meaningful interpretation of obtained signatures to be guaranteed, the low-rank canonical polyadic tensor decomposition is prompted respectively by the sparsity and the non-negativity constraints on the tensor loading matrices. The main objective of this contribution is to propose a new way of tracking brain networks in the context of epileptic iEEG data by identifying the most dominant effective connectivity patterns underlying the observed iEEG signals at each time window. The performance of the proposed method is firstly evaluated on simulated data imitating brain activities and secondly on real intracerebral electroencephalographic signals obtained from an epileptic patient. The partial directed coherence-based tensor has been decomposed into space, time, and frequency signatures in accordance with the expected ground truth for each consecutive sequence of the simulated data. The method is also in accordance with the clinical expertise for iEEG epileptic signals, where the signatures were investigated through a simultaneous multi-seizure analysis.

Mots clés: Canonical polyadic decomposition; Effective connectivity; Partial directed coherence

Domaines: Neurosciences [q-bio.NC]; Traitement du signal et de l'image [eess.SP]; Ingénierie biomédicale

Pierre-Antoine Chantal, Ahmad Karfoul, Anca Nica, Régine Le Bouquin Jeannès. Dynamic brain effective connectivity analysis based on low-rank canonical polyadic decomposition: application to epilepsy. Medical and Biological Engineering and Computing, 2021, 59 (5), pp.1081-1098. ⟨10.1007/s11517-021-02325-x⟩. ⟨hal-03222625⟩