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Article Dans Une Revue Nature Reviews Immunology Année : 2020

Tissue damage from neutrophil-induced oxidative stress in COVID-19

Résumé

The high neutrophil to lymphocyte ratio observed in critically ill patients with COVID-19 is associated with excessive levels of reactive oxygen species (ROS), which promote a cascade of biological events that drive pathological host responses. ROS induce tissue damage, thrombosis and red blood cell dysfunction, which contribute to COVID-19 disease severity. We suggest that free radical scavengers could be beneficial for the most vulnerable patients.
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Dates et versions

hal-03091080 , version 1 (05-01-2021)

Identifiants

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Mireille Laforge, Carole Elbim, Corinne Frère, Miryana Hémadi, Charbel Massaad, et al.. Tissue damage from neutrophil-induced oxidative stress in COVID-19. Nature Reviews Immunology, 2020, 20 (9), pp.515-516. ⟨10.1038/s41577-020-0407-1⟩. ⟨hal-03091080⟩
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