Basal ganglia oscillations: the role of delays and external excitatory nuclei

Ihab Haidar (1) , William Pasillas-Lépine (1) , Elena Panteley (1) , Antoine Chaillet (1)

1 L2S - Laboratoire des signaux et systèmes

Basal ganglia are interconnected deep brain structures involved in movement generation. Their oscillations in the beta band (13-30Hz) is known to be linked to Parkinson's disease motor symptoms. In this paper, we provide conditions under which these oscillations may occur, by explicitly considering the role of the pedunculopontine nucleus (PPN). We analyze the existence of equilibria in the associated firing-rates dynamics , and study their stability by relying on a delayed MIMO frequency analysis. The results are illustrated by simulations.

Mots clés: basal ganglia oscillations; stability of MIMO delayed systems

Domaines: Automatique / Robotique; Neurosciences [q-bio.NC]

Ihab Haidar, William Pasillas-Lépine, Elena Panteley, Antoine Chaillet. Basal ganglia oscillations: the role of delays and external excitatory nuclei. 2012. ⟨hal-00742100v1⟩