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Méthodes multiblocs pour l'identification de gènes associés au vieillissement cutané

Abstract : A study was conducted on 502 women to identify genes affecting skin aging. General and phenotypic data were collected and a blood sample was taken for genetic analysis. The severity of photoaging and 12 signs of skin aging were evaluated from digital photographs of the face with photographic ordinal scales. Three scores were then calculated from these signs of aging. Genotyped SNPs (Single Nucleotide Polymorphisms) allowed identifying 15.198 genes for each of the 502 women. The analysis of the relationship between these genes, photoaging and the scores was performed using a multiblock method associated with a resampling method (bootstrap) to select significative SNPs within each bloc. Blocks of genes containing the number of allelic mutations by SNPs are the independent variables, and scores and photoaging are the variables to be explained.
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Submitted on : Wednesday, March 25, 2020 - 6:24:34 PM
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  • HAL Id : hal-00752243, version 1


Anne Bernard, Arthur Tenenhaus, Jean-François Zagury, Christiane Guinot, Gilbert Saporta. Méthodes multiblocs pour l'identification de gènes associés au vieillissement cutané. JdS'12, May 2012, Bruxelles, Belgique. ⟨hal-00752243⟩



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