Université Paris-Saclay (Espace Technologique, Bat. Discovery - RD 128 - 2e ét., 91190 Saint-Aubin - France)
Abstract : Basal ganglia are interconnected deep brain structures involved in movement generation. Their persistent beta-band oscillations (13-30Hz) are known to be linked to Parkinson's disease motor symptoms. In this paper, we provide conditions under which these oscillations may occur, by explicitly considering the role of the pedunculopontine nucleus (PPN). We analyze the existence of equilibria in the associated firing-rate dynamics and study their stability by relying on a delayed MIMO frequency analysis. Our analysis suggest that the PPN has an influence on the generation of pathological beta-band oscillations. These results are illustrated by simulations that confirm numerically the analytic predictions of our two main theorems.
https://hal-supelec.archives-ouvertes.fr/hal-00978760
Contributor : William Pasillas-Lépine
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Submitted on : Monday, April 14, 2014 - 4:25:39 PM
Last modification on : Tuesday, February 26, 2019 - 10:12:32 AM
