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Closed-loop Deep Brain Stimulation Based on Firing-rate Regulation

Abstract : This paper develops a new closed-loop strategy for deep brain stimulation, derived using a model-based analysis of the basal ganglia. The system is described using a firing-rate model that has been proposed recently in the literature, in order to analyze the generation of beta-band oscillations. On this system, a proportional regulation of the firing-rate compensates the loss of stability of the subthalamo-pallidal loop in the parkinsonian case. Nevertheless, because of actuation and measurement delays in the stimulation device, a filter with a well chosen frequency must be added to such proportional schemes, in order to achieve an adequate stability margin.
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Contributor : William Pasillas-Lépine Connect in order to contact the contributor
Submitted on : Monday, April 14, 2014 - 4:39:13 PM
Last modification on : Thursday, June 17, 2021 - 3:49:28 AM



William Pasillas-Lépine, Ihab Haidar, Antoine Chaillet, Elena Panteley. Closed-loop Deep Brain Stimulation Based on Firing-rate Regulation. IEEE/EMBS NER 2013, Nov 2013, San Diego, United States. pp.166 - 169, ⟨10.1109/NER.2013.6695898⟩. ⟨hal-00978779⟩



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