Phosphatidylserine transport in cell life and death

Alenka Čopič (1) , Thibaud Dieudonné (2) , Guillaume Lenoir (2)

1 CRBM - Centre de recherche en Biologie cellulaire de Montpellier
2 I2BC - Institut de Biologie Intégrative de la Cellule

Phosphatidylserine (PS) is a negatively-charged glycerophospholipid found mainly in the plasma membrane (PM) and in the late secretory/endocytic compartments, where it regulates cellular activity and can mediate apoptosis. Export of PS from the endoplasmic reticulum, its site of synthesis, to other compartments, and its transbilayer asymmetry must therefore be precisely regulated. We review recent findings on non-vesicular transport of PS by lipid transfer proteins (LTPs) at membrane contact sites, on PS flip-flop between membrane leaflets by flippases and scramblases, and on PS nano-clustering at the PM. We also discuss emerging data on cooperation between scramblases and LTPs, how perturbation of PS distribution can lead to disease, and the specific role of PS in viral infection.

Mots clés: Phosphatidylserine Lipid transfer protein Flippase Scramblase Lipid nanodomain Membrane Asymmetry Viral Infection; Phosphatidylserine; Lipid transfer protein; Flippase; Scramblase; Lipid nanodomain; Membrane Asymmetry; Viral Infection

Domaines: Organisation et fonctions cellulaires [q-bio.SC]

Alenka Čopič, Thibaud Dieudonné, Guillaume Lenoir. Phosphatidylserine transport in cell life and death. Current Opinion in Cell Biology, 2023, Special Issue on Membrane Trafficking, 83, pp.102192. ⟨10.1016/j.ceb.2023.102192⟩. ⟨hal-04275033⟩